ANCIENT URBANIZATION PREDICTS GENETIC RESISTANCE TO TUBERCULOSIS
Identifieur interne : 000485 ( Main/Exploration ); précédent : 000484; suivant : 000486ANCIENT URBANIZATION PREDICTS GENETIC RESISTANCE TO TUBERCULOSIS
Auteurs : Ian Barnes [Royaume-Uni] ; Anna Duda [Royaume-Uni] ; Oliver G. Pybus [Royaume-Uni] ; Mark G. Thomas [Royaume-Uni, Suède]Source :
- Evolution [ 0014-3820 ] ; 2011-03.
English descriptors
- KwdEn :
Abstract
A link between urban living and disease is seen in recent and historical records, but the presence of this association in prehistory has been difficult to assess. If the transition to urban living does result in an increase in disease‐based mortality, we might expect to see evidence of increased disease resistance in longer‐term urbanized populations, as the result of natural selection. To test this, we determined the frequency of an allele (SLC11A1 1729 + 55del4) associated with natural resistance to intracellular pathogens such as tuberculosis and leprosy. We found a highly significantly correlation with duration of urban settlement—populations with a long history of living in towns are better adapted to resisting these infections. This correlation remains strong when we correct for autocorrelation in allele frequencies due to shared population history. Our results therefore support the interpretation that infectious disease loads became an increasingly important cause of human mortality after the advent of urbanization, highlighting the importance of population density in determining human health and the genetic structure of human populations.
Url:
DOI: 10.1111/j.1558-5646.2010.01132.x
Affiliations:
- Royaume-Uni, Suède
- Angleterre, East Middle Sweden, Grand Londres, Oxfordshire, Svealand
- Londres, Oxford, Uppsala
- University College de Londres, Université d'Oxford, Université d'Uppsala, Université de Londres
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001436
- to stream Istex, to step Curation: 000E39
- to stream Istex, to step Checkpoint: 000335
- to stream Main, to step Merge: 000486
- to stream Main, to step Curation: 000485
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">ANCIENT URBANIZATION PREDICTS GENETIC RESISTANCE TO TUBERCULOSIS</title><author><name sortKey="Barnes, Ian" sort="Barnes, Ian" uniqKey="Barnes I" first="Ian" last="Barnes">Ian Barnes</name></author><author><name sortKey="Duda, Anna" sort="Duda, Anna" uniqKey="Duda A" first="Anna" last="Duda">Anna Duda</name></author><author><name sortKey="Pybus, Oliver G" sort="Pybus, Oliver G" uniqKey="Pybus O" first="Oliver G." last="Pybus">Oliver G. Pybus</name></author><author><name sortKey="Thomas, Mark G" sort="Thomas, Mark G" uniqKey="Thomas M" first="Mark G." last="Thomas">Mark G. Thomas</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6380DBEA357D7547644862EF0BFC6288AAAA4E6C</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1111/j.1558-5646.2010.01132.x</idno><idno type="url">https://api.istex.fr/document/6380DBEA357D7547644862EF0BFC6288AAAA4E6C/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001436</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001436</idno><idno type="wicri:Area/Istex/Curation">000E39</idno><idno type="wicri:Area/Istex/Checkpoint">000335</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000335</idno><idno type="wicri:doubleKey">0014-3820:2011:Barnes I:ancient:urbanization:predicts</idno><idno type="wicri:Area/Main/Merge">000486</idno><idno type="wicri:Area/Main/Curation">000485</idno><idno type="wicri:Area/Main/Exploration">000485</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">ANCIENT URBANIZATION PREDICTS GENETIC RESISTANCE TO TUBERCULOSIS</title><author><name sortKey="Barnes, Ian" sort="Barnes, Ian" uniqKey="Barnes I" first="Ian" last="Barnes">Ian Barnes</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Biological Sciences, Royal Holloway, University of London, Egham Hill, Egham, Surrey, TW20 9BE</wicri:regionArea><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Duda, Anna" sort="Duda, Anna" uniqKey="Duda A" first="Anna" last="Duda">Anna Duda</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Department of Genetics, Evolution and Environment, University College London, Gower Street, London, WC1E 6BT</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pybus, Oliver G" sort="Pybus, Oliver G" uniqKey="Pybus O" first="Oliver G." last="Pybus">Oliver G. Pybus</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS</wicri:regionArea><orgName type="university">Université d'Oxford</orgName><placeName><settlement type="city">Oxford</settlement><region type="nation">Angleterre</region><region type="région" nuts="1">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Thomas, Mark G" sort="Thomas, Mark G" uniqKey="Thomas M" first="Mark G." last="Thomas">Mark G. Thomas</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Research Department of Genetics, Evolution and Environment, University College London, Gower Street, London, WC1E 6BT</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE‐752 36 Uppsala</wicri:regionArea><orgName type="university">Université d'Uppsala</orgName><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Evolution</title><title level="j" type="sub">International Journal of Organic Evolution</title><idno type="ISSN">0014-3820</idno><idno type="eISSN">1558-5646</idno><imprint><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2011-03">2011-03</date><biblScope unit="volume">65</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="842">842</biblScope><biblScope unit="page" to="848">848</biblScope></imprint><idno type="ISSN">0014-3820</idno></series><idno type="istex">6380DBEA357D7547644862EF0BFC6288AAAA4E6C</idno><idno type="DOI">10.1111/j.1558-5646.2010.01132.x</idno><idno type="ArticleID">EVO1132</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-3820</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Disease resistance</term><term>evolution</term><term>human</term><term>pathogen</term><term>tuberculosis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A link between urban living and disease is seen in recent and historical records, but the presence of this association in prehistory has been difficult to assess. If the transition to urban living does result in an increase in disease‐based mortality, we might expect to see evidence of increased disease resistance in longer‐term urbanized populations, as the result of natural selection. To test this, we determined the frequency of an allele (SLC11A1 1729 + 55del4) associated with natural resistance to intracellular pathogens such as tuberculosis and leprosy. We found a highly significantly correlation with duration of urban settlement—populations with a long history of living in towns are better adapted to resisting these infections. This correlation remains strong when we correct for autocorrelation in allele frequencies due to shared population history. Our results therefore support the interpretation that infectious disease loads became an increasingly important cause of human mortality after the advent of urbanization, highlighting the importance of population density in determining human health and the genetic structure of human populations.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>Suède</li></country><region><li>Angleterre</li><li>East Middle Sweden</li><li>Grand Londres</li><li>Oxfordshire</li><li>Svealand</li></region><settlement><li>Londres</li><li>Oxford</li><li>Uppsala</li></settlement><orgName><li>University College de Londres</li><li>Université d'Oxford</li><li>Université d'Uppsala</li><li>Université de Londres</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Barnes, Ian" sort="Barnes, Ian" uniqKey="Barnes I" first="Ian" last="Barnes">Ian Barnes</name></region><name sortKey="Duda, Anna" sort="Duda, Anna" uniqKey="Duda A" first="Anna" last="Duda">Anna Duda</name><name sortKey="Pybus, Oliver G" sort="Pybus, Oliver G" uniqKey="Pybus O" first="Oliver G." last="Pybus">Oliver G. Pybus</name><name sortKey="Thomas, Mark G" sort="Thomas, Mark G" uniqKey="Thomas M" first="Mark G." last="Thomas">Mark G. Thomas</name><name sortKey="Thomas, Mark G" sort="Thomas, Mark G" uniqKey="Thomas M" first="Mark G." last="Thomas">Mark G. Thomas</name></country><country name="Suède"><region name="Svealand"><name sortKey="Thomas, Mark G" sort="Thomas, Mark G" uniqKey="Thomas M" first="Mark G." last="Thomas">Mark G. Thomas</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Linguistique/explor/TamazightV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000485 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000485 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Linguistique
|area= TamazightV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:6380DBEA357D7547644862EF0BFC6288AAAA4E6C
|texte= ANCIENT URBANIZATION PREDICTS GENETIC RESISTANCE TO TUBERCULOSIS
}}
| This area was generated with Dilib version V0.6.33. |  |